Immunogenicity of Diphtheria-Tetanus-Acellular Pertussis Vaccine Combined with Haemophilus influenzae Type b Polysaccharide-Tetanus Toxoid Conjugate Vaccine (DTaPH) in 2, 4, and 6 Month Old Infants ♦ 812

Autor:	Henry H. Bernstein, Evelyn A. Kurt-Jones, Colin D. Marchant, Krista Garrison
Rok vydání:	1998
Předmět:	Tetanus business.industry Immunogenicity Diphtheria Toxoid Filamentous haemagglutinin adhesin medicine.disease complex mixtures Virology Conjugate vaccine Pediatrics Perinatology and Child Health Immunology medicine Pertussis vaccine business Conjugate medicine.drug
Zdroj:	Pediatric Research. 43:141-141
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199804001-00833
Popis:	Two hundred seventy-five infants were randomly assigned to receive either DTaPH or a Diphtheria-Tetanus-Acellular Pertussis Vaccine (DTaP) and one of two Hib conjugate vaccines as separate injections. DTaPH contained either 25 or 50 μg of pertussis toxoid (PT), 3 μg of filamentous hemagglutinin(FHA), 10 lf of diphtheria (diph), and either 5, 2.5, or 1 lf of tetanus(tet) and 10 μg of Hib-tetanus conjugate vaccine(mHib-T). Connaught DTaP vaccine(23 μg each of PT and FHA, 6.7 lf diph, 5 lf tet) and either 10 μg of mHib-T or Wyeth-Lederle Hib-CRM197 conjugate vaccine (HbOC) were given in the separate injection groups. Each infant received the same vaccines as 0.5 ml IM injections in the anterolateral thighs at 2, 4, and 6 months. Other routinely recommended vaccines were also given. Immune responses to Hib by Farr assay 1 month after the third set are indicated in the table below. Immune responses to mHib-T and HbOC were comparable. GMC to Hib after DTaPH was lower than that obtained after mHib-T(p
Databáze:	OpenAIRE
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