Resistance to cellobiose lipids and specific features of lipid composition in yeast
| Autor: | Alexey A. Mironov, E. V. Kulakovskaya |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ergosterol Strain (chemistry) biology Microorganism 030106 microbiology Saccharomyces cerevisiae Mutant Cellobiose biology.organism_classification Applied Microbiology and Biotechnology Biochemistry Yeast 03 medical and health sciences chemistry.chemical_compound chemistry lipids (amino acids peptides and proteins) Sphingomyelin |
| Zdroj: | Applied Biochemistry and Microbiology. 52:615-620 |
| ISSN: | 1608-3024 0003-6838 |
| DOI: | 10.1134/s0003683816060107 |
| Popis: | The significance of the fatty acid composition and ergosterol content in cells for resistance to cellobiose lipids has been investigated in the cells of mutant Saccharomyces cerevisiae strains that are unable to produce ergosterol or sphingomyelin and in the cells of microorganisms that produce cellobiose lipids. S. cerevisiae mutants were shown to be less sensitive to cellobiose lipids from Cryptococcus humicola than the wild-type strain, and the strains that produced cellobiose lipids were virtually insensitive to this compound as well. The sensitivity of Pseudozyma fusiformata yeast to its own cellobiose lipids was reduced under conditions that favored the production of these compounds. No correlation between the content of ergosterol and sensitivity to cellobiose lipids was observed in S. cerevisiae or in the strains that produced cellobiose lipids. The ratio between the levels of saturated and unsaturated fatty acids in the cells of the mutant strains was correlated to the sensitivity of the cells to cellobiose lipids. |
| Databáze: | OpenAIRE |
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