The Crosstalk of RAS with the TGF-β Family During Carcinoma Progression and its Implications for Targeted Cancer Therapy
| Autor: | Doris Schneller, Wolfgang Mikulits, Michaela Petz, Thomas Metzner, Michael Grusch, Deniz Oztürk |
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| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
0303 health sciences Cancer Research Cancer therapy Biology medicine.disease_cause medicine.disease 3. Good health 03 medical and health sciences Crosstalk (biology) 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Anti-apoptotic Ras signalling cascade Drug Discovery Immunology Tumor stage Cancer research medicine Carcinoma Carcinogenesis 030304 developmental biology Transforming growth factor |
| Zdroj: | Current Cancer Drug Targets. 10:849-857 |
| ISSN: | 1568-0096 |
| DOI: | 10.2174/156800910793357943 |
| Popis: | Both RAS and transforming growth factor (TGF)-β signaling cascades are central in tumorigenesis and show synergisms depending on tumor stage and tissue context. In this review we focus on the interaction of RAS subeffector proteins with signaling components of the TGF-β family including those of TGF-βs, activins and bone morphogenic proteins. Compelling evidence indicates that RAS signaling is essentially involved in the switch from tumor-suppressive to tumor-promoting functions of the TGF-β family leading to enhanced cancer growth and metastatic dissemination of primary tumors. Thus, the interface of these signaling cascades is considered as a promising target for the development of novel cancer therapeutics. The current pharmacological anti-cancer concepts combating the molecular cooperation between RAS and TGF-β family signaling during carcinoma progression are critically discussed. |
| Databáze: | OpenAIRE |
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