Radiobiological concepts for treatment planning of schemes that combines external beam radiotherapy and systemic targeted radiotherapy
| Autor: | Joaquín Jorge González González, Carlos Calderón Marín, Rodolfo Alfonso Laguardia |
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| Rok vydání: | 2017 |
| Předmět: |
Physics
Nuclear and High Energy Physics medicine.medical_specialty Modalities Modality (human–computer interaction) Targeted Radiotherapy medicine.medical_treatment Normal tissue Tumor control 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Medical physics External beam radiotherapy Radiation treatment planning Instrumentation |
| Zdroj: | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 865:152-156 |
| ISSN: | 0168-9002 |
| DOI: | 10.1016/j.nima.2017.01.059 |
| Popis: | The combination of radiotherapy modalities with external bundles and systemic radiotherapy (CIERT) could be a reliable alternative for patients with multiple lesions or those where treatment planning maybe difficult because organ(s)-at-risk (OARs) constraints. Radiobiological models should have the capacity for predicting the biological irradiation response considering the differences in the temporal pattern of dose delivering in both modalities. Two CIERT scenarios were studied: sequential combination in which one modality is executed following the other one and concurrent combination when both modalities are running simultaneously. Expressions are provided for calculation of the dose-response magnitudes Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP). General results on radiobiological modeling using the linear-quadratic (LQ) model are also discussed. Inter-subject variation of radiosensitivity and volume irradiation effect in CIERT are studied. OARs should be under control during the planning in concurrent CIERT treatment as the administered activity is increased. The formulation presented here may be used for biological evaluation of prescriptions and biological treatment planning of CIERT schemes in clinical situation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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