Molecular epidemiology of rotavirus in four provinces of Angola before vaccine introduction
| Autor: | Nilton Saraiva, Joana Castro Pereira, Rafael Dimbu, Cristina Mendes, Filomeno Fortes, Aida Esteves, Claudia Istrate, Johan Nordgren |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Molecular epidemiology Phylogenetic tree business.industry Reassortment Disease cluster medicine.disease_cause Rotavirus vaccine Virology 03 medical and health sciences 030104 developmental biology Infectious Diseases Rotavirus Epidemiology Genotype medicine business |
| Zdroj: | Journal of Medical Virology. 88:1511-1520 |
| ISSN: | 0146-6615 |
| Popis: | Angola is a sub-Saharan country in southern Africa highly affected by diarrhoeal disease with limited epidemiological data regarding etiologic agents. This study was performed during 2012-2013, prior to rotavirus vaccine introduction, with the objective to detect and characterize the rotavirus strains circulating in four provinces of the country: Huambo, Luanda, Zaire, and Cabinda. A high rotavirus detection rate (35%, 117/334) was observed. G1 was the most common G-genotype (83.6%), whereas P[8] (50.9%) followed by P[6] (38.8%) were the most common P-types. G1P[8] was identified as the predominant combination (50%), followed by the unusual G1P[6] (29.3%). Strains such G2P[4], G8P[6], G9P[6], and G12P[6] were also found in lower frequencies (5.2-1.7%). The P[6] strains did not cluster in the phylogenetic trees according to their geographic origin or even the corresponding G-genotype, suggesting a limited number of recent introductions and extensive reassortment events. Our results represent the first report on rotavirus genotype profiles in Angola, showing a wide circulation of the unusual genotype G1P[6], and underline the importance of RV surveillance after the vaccine introduction. J. Med. Virol. 88:1511-1520, 2016. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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