Pharmacological Advances of Chloroquine and Hydroxychloroquine: From Antimalarials to Investigative Therapies in COVID-19
| Autor: | Yang Song, Elise Fields |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Plant Science medicine.disease_cause law.invention 03 medical and health sciences 0302 clinical medicine law Chloroquine Drug Discovery Pandemic Medicine Coronavirus Pharmacology Clinical pharmacology business.industry Hydroxychloroquine General Medicine Virology 030104 developmental biology Complementary and alternative medicine 030220 oncology & carcinogenesis business medicine.drug |
| Zdroj: | Natural Product Communications. 15:1934578X2095364 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | During the coronavirus disease 2019 (COVID-19) pandemic, numerous existing chemicals have been screened for antiviral potential against the emerging coronavirus severe acute respiratory syndrome coronavirus 2. Chloroquine and hydroxychloroquine, after exhibiting potent in vitro efficacy, have gained tremendous attention. Both therapeutics are derivatives of natural alkaloid quinine and were first synthesized to treat malaria. Thereafter, the pharmaceutical applications of the agents have expanded to many new areas. In this article, the medicinal history and pharmacological activities of chloroquine and hydroxychloroquine are summarized. Antimalarial, anti-inflammatory, antitumor, antiviral properties, and therapeutic potential in the emerging viral infection COVID-19 are discussed. Pharmacokinetics, adverse effects, and toxicities are reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|