ChemInform Abstract: The Synthesis and Some Manipulations of Dialkyl 6-Aryl(or Alkyl)-2- oxotetrahydro-2H-pyran-3,5-dicarboxylates

Autor:	Patrick Perlmutter, R. M. Lawrence
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Addition reaction chemistry.chemical_compound Annulation Malonate Chemistry Pyran Aryl Organic chemistry Stereoselectivity General Medicine Alkyl Conjugate
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199710114
Popis:	A new, one-pot annulation process, involving conjugate addition of the sodium salts of dimethyl (or dibenzyl ) malonate to alkyl 2-(1- hydroxyalkyl ) propenoates, produces a mixture of dialkyl 6-aryl(or alkyl)-2-oxotetrahydro-2H-pyran-3,5-dicarboxylates. Alkylations of the cis-isomers were found to be highly stereoselective . The ntroduction of unsaturation into these molecules is also described.
Databáze:	OpenAIRE
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