SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HETEROCYCLES CONTAINING OXADIAZOLE AND PYRAZOLE RING FOR ANTI-BACTERIAL, ANTI-FUNGAL AND ANTI-TUBERCULAR ACTIVITIES

Autor:	P. A. Chavan, K. D. Pansare, S. V. Hiremath, R. A. Muluk, P-Loni, Tal Rahata Dist. Ahmednagar, Pin , Maharashtra., J. S. Pattan, S. S. Dengale, S. S. Vetal, S. R. Pattan
Rok vydání:	2012
Předmět:	Pharmacology chemistry.chemical_compound chemistry Stereochemistry Drug Discovery Pharmaceutical Science Oxadiazole Anti fungal Anti bacterial Pyrazole Anti tubercular Ring (chemistry) Biological evaluation
Zdroj:	INDIAN DRUGS. 49:18-24
ISSN:	0019-462X
DOI:	10.53879/id.49.03.p0018
Popis:	1, 3, 4-oxadiazoles were synthesized by treating pyrazine-2-carbohydrazide with CS2 and alc. KOH and their derivatives were prepared by using R-Cl compounds. pyrazolones were synthesized by treatingpyrazine-2-carbohydrazide with ethyl acetoacetate. The derivatives of pyrazolone were prepared by refluxing pyrazolone with formaldehyde and different substituted secondary amines. All the synthesized compounds were characterized by IR, 1H-NMR and elemental analysis and evaluated for antibacterial, antifungal and antitubercular activities.
Databáze:	OpenAIRE
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