Synthesis of l-Ribose from d-Ribose by a Stereoconversion through Sequential Lactonization as the Key Transformation

Autor:	Hakjune Rhee, Byunghoon Lee, Saira Shabbir, Jaeyoung Ban, Minkyung Lim
Rok vydání:	2017
Předmět:	Transformation (genetics) chemistry.chemical_compound 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Ribose Key (cryptography) 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences
Zdroj:	Synthesis. 49:4299-4302
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0036-1588857
Popis:	l-Ribose, a key precursor of various l-nucleosides can only be synthesized from other sugars or other non-sugar precursors. Herein, the study involves the synthesis of naturally rare l-ribose from readily available d-ribose. Though, many synthetic strategies are developed to meet the increasing demands of l-ribose, seeking innovation, a synthesis employing sequential lactonization as the key transformation was explored. This novel conversion involves protection, oxidation, sequential lactonization, reduction with DIBAL-H, and deprotection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::54825a86adfba6212ebdde9e098de123 https://doi.org/10.1055/s-0036-1588857 Zobrazit plný text záznamu