Culturing Caenorhabditis elegans on Escherichia coli Strains Lacking the Synthesis of bo' and bd-I Terminal Oxidases Extends the Nematode Lifespan
| Autor: | R. S. Shakulov, Olga Katkova-Zhukotskaya, Alexander Mironov, S. Yu. Eremina |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
chemistry.chemical_classification 0303 health sciences Reactive oxygen species Mutant Biology biology.organism_classification medicine.disease_cause 01 natural sciences Microbiology 03 medical and health sciences Nematode chemistry Genetics medicine Escherichia coli Bacteria Caenorhabditis elegans Oxidative stress 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Russian Journal of Genetics. 55:1573-1576 |
| ISSN: | 1608-3369 1022-7954 |
| DOI: | 10.1134/s1022795419120068 |
| Popis: | The effect of E. colicyoA and cydA mutations that diminish the activity of bo' and bd-I terminal oxidases, respectively, on the lifespan of C. elegans nematodes was examined. It was demonstrated that the mean lifespan of the nematodes feeding on the cyoA and cydA mutants increased by 15.5 and 12.8%, respectively. It is known that cyoA and cydA mutants are characterized by the increased level of reactive oxygen species production. It is suggested that the lifespan extension in C. elegans is determined by moderate oxidative stress that occurs in the nematode organism upon culturing on these mutant bacteria. |
| Databáze: | OpenAIRE |
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