| Autor: |
David Olivier, Charvet Guillaume, Depaulis Antoine, Gharbi Sadok, Saillet Sandrine, Guillemaud Regis |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
2009 4th International IEEE/EMBS Conference on Neural Engineering. |
| Popis: |
This preliminary study constitutes a proof of concept for seizure-triggered neuromodulation in a genetic rat model of absence epilepsy (GAERS) using the BioMEA™ system. BioMEA™ is a 256-channel MEA system with integrated electronics (ASIC) allowing simultaneous recording and stimulation of neural networks in vitro. It is based on parallel architecture of 64-channel ASICs with recording and stimulation capabilities for each channel. Here, we show that BioMEA™ can also be used to develop adaptive protocols of neurostimulation in vivo. In epileptic rats, a seizure detection algorithm delivered online command to BioMEA™ for bilateral stimulation of the substantia nigra pars reticulata which aborted spike-and-wave discharges in many instances, within 1 second following seizure onset. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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