P1‐298: Memantine: Assessment in novel object recognition and quantitative 2‐deoxyglucose metabolism in rat
| Autor: | Jonathan Papworth, Alexander Syme, Anthony Groom, Adam Lucas, Lee Dawson, Toshal Patel, Janette Robertson, Jane Gartlon |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Epidemiology business.industry Health Policy Deoxyglucose Population Memantine Pharmacology medicine.disease Cardiac surgery Psychiatry and Mental health Cellular and Molecular Neuroscience Developmental Neuroscience Clinical decision making Internal medicine Anesthesiology medicine Dementia Neurology (clinical) Geriatrics and Gerontology Novel object recognition education business medicine.drug |
| Zdroj: | Alzheimer's & Dementia. 8 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | dementia. Conclusions: Our findings indicate that following cardiac surgery the number of individuals identified as at risk of dementia is much higher than expected in the general population (0.3-0.8% per year) as more than 50% of individuals were affected. Equally concerning are the results following non-cardiac surgery and minor procedures at one year showing 13% and 18% (respectively) of individuals at risk of dementia. These results may have significant implications for clinical decision making in healthcare, and may provide a model for therapeutic intervention AD trials. References: 1 Evered, L et al. Anesth Analg 2011; 112: 1179-85, 2 Xie,Z and Tanzie, R. Exp Gerontol 2006; 41:346-59, 3 Baranov, D et al. Anesth Analg 2009; 108:1627-30, 4 Silbert et al. Anesthesiology 2006; 104: 1137-45. |
| Databáze: | OpenAIRE |
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