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The study demonstrates the significance of development mechanism of age-related cataract consequent to the loss of barrier properties of the lens capsule based on analysis of the accumulation of sodium, calcium, phosphorus and potassium. Spatial cluster analysis and correlation analysis were used to reveal for the first time the relation between the diffusion of light in the body of the crystalline lens and changes in its elemental composition. Distribution fields of elevated concentrations of sodium, calcium, phosphorus, potassium and chlorine are consistent with geometry of the lens capsule and clusterize together with areas of opacification in its body. The accumulation geometry of the elements in the lens body is also commonly seen in the aqueous humor of the anterior chamber, which can be considered evidence for excessive transitioning of their compounds through the lens capsule shell, while spatial connection with transparency changes - proof of its participation in cataractogenesis. |
