SNPs and TFBS Associated with High Altitude Sickness*

Autor:	C. Ronald Scott, Xue-Han Ning, Xiu-Feng Wu, Zhao-Nian Zhou, Wei-Zhong Zhu, Shi-Han Chen, Wei-Jun Cen, Norman E. Buroker, Kui Li
Rok vydání:	2013
Předmět:	Genetics biology Single-nucleotide polymorphism Effects of high altitude on humans Hypoxia (medical) Geography Gene expression biology.protein medicine Allele medicine.symptom Transcription factor Gene EGLN1
Zdroj:	Open Journal of Blood Diseases. :85-93
ISSN:	2164-3199 2164-3180
Popis:	The rSNPs for the genes AKT3 (rs4590656), EGLN1 (rs480902), eNOS3 (rs1007311), and VEGFA (rs699947, rs13207311, rs1570360, rs2010963) have been significantly associated with the physiological parameters in high altitude sickness Han or Tibetan Chinese patients at the Qinghai-Tibetan plateau. The alleles of each rSNP have been found to create unique transcriptional factor binding sites for transcription factors that affect the process of hypoxia gene expression in this high altitude hypoxia environment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::54720d32e0c065f55c27ec190b2a06e2 https://doi.org/10.4236/ojbd.2013.33018 Zobrazit plný text záznamu