Impact of pre-transplant infection management on the outcome of living-donor liver transplantation in Egypt
| Autor: | Heba Fadl Elsergany, Eman Ibrahim El-Desoki Mahmoud, Sherief Abd-Elsalam, Mohamed Ismail Seleem, Ahmed A. Gomaa, Ahmed M. Saleh, Essam A. Hassan, Yousry Esam-Eldin Abo-Amer, Mohamed El-Abgeegy, Tamer Mahmoud El Baz |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty Cirrhosis business.industry Mortality rate medicine.medical_treatment 030106 microbiology Liver transplantation medicine.disease Chronic liver disease Transplantation Sepsis 03 medical and health sciences Liver disease 0302 clinical medicine Infectious Diseases Concomitant Internal medicine medicine Pharmacology (medical) 030212 general & internal medicine business |
| Zdroj: | Infection and Drug Resistance. 12:2277-2282 |
| ISSN: | 1178-6973 |
| Popis: | Background and aim Liver transplantation (LT) has emerged as an established therapeutic option for patients with chronic liver disease. Patients with end-stage liver disease are at high risk of infection with multidrug-resistant organisms, which may affect the outcome of LT. The aim of this study was to evaluate the impact of pre-transplant infection on the outcome of living-donor LT. Methods Prospective follow-up was done for 50 patients with chronic liver disease who had had LT performed from September 2013 to December 2017. We divided patients into group 1 (patients who had had infection within 3 months before transplantation with adequate treatment [n=20]), and group 2 (patients without infection [n=30]). Both groups were followed for 4 months post-operatively. Results Patients with high Model for End-Stage Liver Disease scores were more susceptible to infection pre- and post-operatively, and chest infection was the most common infection pre-transplant. There were no significant statistical differences regarding hospital and ICU stay and post-operative course between the groups, but the mortality rate was higher in group 1 (40%) than in group 2 (23.3%), and the causes of mortality in the group 1 were mainly due to medical causes (infections and sepsis, 75%) versus 28.6% in group 2. Conclusion Liver-cell failure and concomitant infection 3 months before LT with adequate treatment had no significant statistical differences regarding hospital, ICU stay, or medical complications, but post-operative infection and mortality rate were more frequent in group 1 and the causes of mortality were mainly medical. |
| Databáze: | OpenAIRE |
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