PET with 18F-DOPA in the imaging of parathyroid adenoma in patients with primary hyperparathyroidism
| Autor: | Ernst Moser, A. Lange-Nolde, T. Zajic, M. Slawik, I. Brink, M. Reincke, Stefan Hoegerle |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry General Medicine Gold standard (test) Scintigraphy medicine.disease 18f dopa Positron emission tomography medicine Radiology Nuclear Medicine and imaging In patient Radiology Ultrasonography Nuclear medicine business Primary hyperparathyroidism Parathyroid adenoma |
| Zdroj: | Nuklearmedizin. 45:193-196 |
| ISSN: | 2567-6407 0029-5566 |
| DOI: | 10.1055/s-0038-1625218 |
| Popis: | Summary:Preoperative localization of parathyroid adenomas (PA) can shorten operation time and improve curative rate; it becomes especially important in minimally invasive surgical techniques. Aim of this study was to investigate whether positron emission tomography (PET) with 3-,4-dihydroxy- 6-18F-fluorophenylalanine (18F-DOPA), which showed very promising results in other neuroendocrine tumours, also helps to localize PA. Patients, methods: Eight patients with proven primary hyperparathyroidism were studied preoperatively with PET. Seven also underwent scintigraphy with 99mTc-MIBI and ultrasonography of the neck. All patients were operated and the histological finding was used as a gold standard. Results: All eight patients had a histologically proven PA. None of the PA showed any detectable uptake of 18F-DOPA. However, ultrasonography detected 5/7 PA, scintigraphy detected 3/7 PA. Conclusion: These results suggest that PET with 18F-DOPA is not useful in the detection of PA in patients with primary hyperparathyroidism. |
| Databáze: | OpenAIRE |
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