ChemInform Abstract: Structural and Biological Properties of Vermistatin and Two New Vermistatin Derivatives Isolated from the Marine-Mangrove Endophytic Fungus Guignardia sp. No. 4382

Autor:	Yongcheng Lin, Li Wu Fu, Zhigang She, Liu Lan, Jian Ye Zhang, Ji Wen Cai, Xuekui Xia, Hua Rong Huang, L. L. P. Vrijmoed
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Circular dichroism chemistry Stereochemistry Biological property Vermistatin Fungal strain General Medicine Guignardia sp Mangrove Endophytic fungus In vitro
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
Popis:	Vermistatin (=(3R)-4,6-dimethoxy-3-{4-oxo-6-[(1E)-prop-1-en-1-yl]-4H-pyran-3-yl}-2-benzofuran-1(3H)-one; 1) and two new vermistatin derivatives, compounds 2 and 3, were isolated from the fungal strain Guignardia sp. No. 4382 obtained from the South-China Sea. Their structures were elucidated by various methods, including circular dichroism (CD), 1D- and 2D-NMR, and HR-EI-MS. The structures of 1 and 2 were unequivocally corroborated by X-ray crystallography, and their absolute configurations were derived by CD spectroscopy based on a literature comparison. The in vitro cytotoxic and antifungal activities of 1 and 2 were tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::545a684c9adaaf692ecaee713e381485 https://doi.org/10.1002/chin.200807192 Zobrazit plný text záznamu Plný text