A study of bacterial sepsis and its relation to thrombocytopenia in neonates
| Autor: | Gautam Mohan Kabbin, Vikram R. Goudar, Shriharsha Badiger, Suhas N. Joshi, Vinod P. Chavan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Klebsiella
medicine.medical_specialty biology Klebsiella pneumoniae business.industry medicine.drug_class Birth weight Incidence (epidemiology) Antibiotics biology.organism_classification medicine.disease Sepsis 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine Immunology 030221 ophthalmology & optometry medicine Platelet 030212 general & internal medicine business |
| Zdroj: | International Journal of Contemporary Pediatrics. 4:1032 |
| ISSN: | 2349-3291 2349-3283 |
| DOI: | 10.18203/2349-3291.ijcp20171722 |
| Popis: | Background: In developing countries like India, the culture facilities are non-existent in most of the district hospitals, so the burden of identification of sepsis lies on hematological investigations like platelet count and white blood cells and very few indian studies have been done to show the association . Objectives: 1) To know the incidence of thrombocytopenia in babies with proven bacterial sepsis. 2) To find, if any, species specific differences in severity and incidence of thrombocytopenia. 3) Clinical outcomes in thrombocytopenic and nonthrombocytopenic septic babies. Methods: It is a prospective observational hospital based study. All the neonates admitted to our NICU with probable sepsis were screened for sepsis and neonates with birth weight of 1000 grams and above with blood and/or Cerebrospinal Fluid (CSF) culture positivity for bacterial growth were recruited during the study period from November 2011 to October 2012. A total of 100 neonates with blood and/or CSF culture positivity for bacterial growth were considered convenient for the study. Results: During the present study period of 1 year we had a total of 960 Neonates admitted to our NICU. 475 neonates were screened for sepsis. A total of 100 neonates with blood and/or CSF culture positivity for bacterial growth were considered for the study. Klebsiella pneumoniae sepsis was the highest contributor to the severe thrombocytopenia category (15 out of 29cases). Out of the 100 cases, 41 had normal platelet count and 59 had thrombocytopenia. Klebsiella positivity was more significantly associated with severe thrombocytopenia than MRCONS positivity or rest of the cultures combined together (p value |
| Databáze: | OpenAIRE |
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