Phosphorylation of Betti Base with Bis(diethylamino)phosphoryl Chloride

Autor:	Vladimir A. Alfonsov, K. E. Metlushka, D. N. Sadkova, Olga N. Kataeva, K. A. Nikitina, Kamil A. Ivshin, Zilya Yamaleeva
Rok vydání:	2018
Předmět:	chemistry.chemical_classification Phosphoryl chloride Base (chemistry) 010405 organic chemistry Salt (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Thiourea Phosphorylation
Zdroj:	Russian Journal of General Chemistry. 88:2453-2456
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363218110348
Popis:	The reaction of bis(diethylamino)phosphoryl chloride with N-Boc-protected 1-(α-aminobenzyl)-2- naphthol (Betti base) proceeded via O-phosphorylation of the phenolic OH group to form the target product as trifluoroacetate salt. The latter reacted with O,O-diethyl thiophosphorylisothiocyanate to give thiourea bearing a chiral Betti base fragment.
Databáze:	OpenAIRE
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