Passive transfer of demyelination by serum or IgG from chronic inflammatory demyelinating polyneuropathy patients

Autor:	Jude Taylor, John D. Pollard, Susan Andrias‐Kauba, Wei Xing Yan
Rok vydání:	2000
Předmět:	business.industry Multiple sclerosis Autoantibody Schwann cell Polyradiculoneuropathy Chronic inflammatory demyelinating polyneuropathy medicine.disease Pathogenesis Transplantation Myelin medicine.anatomical_structure Neurology Immunology medicine Neurology (clinical) business
Zdroj:	Annals of Neurology. 47:765-775
ISSN:	1531-8249 0364-5134
Popis:	Chronic inflammatory demyelinating polyneuropathy (CIDP) is regarded as an autoimmune disorder, but no clearly defined autoimmune mechanism has been described. Although most patients respond to plasma exchange, no convincing role for autoantibodies has yet been demonstrated. In this study, we have successfully passively transferred disease using sera and purified IgG from 4 of 12 patients responsive to plasma exchange by bypassing the blood-nerve barrier by intraneural injection or opening it by activated T cells. The sera from CIDP patients or purified IgG produced marked conduction block and demyelination, but normal sera or IgG or that from patients with multiple sclerosis or other neuropathies did not. These observations strongly support an important role for anti-myelin/Schwann cell autoantibodies in the pathogenesis of CIDP at least in some patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5443df178707f6bc2bea1bebf99fd010 https://doi.org/10.1002/1531-8249(200006)47:6<765::aid-ana9>3.0.co Zobrazit plný text záznamu Plný text