Increased Risk of Liver-Related Outcomes in Chronic Hepatitis B Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis
| Autor: | Khin Naing Thin, Andrew Tran, Jie Li, Eunice Yewon Lee, Hongli Yang, Fajuan Rui, Chuanli Liu, Christopher D. Stave, Ramsey C. Cheung, Mindie H. Nguyen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Digestive Diseases. 40:745-753 |
| ISSN: | 1421-9875 0257-2753 |
| DOI: | 10.1159/000521768 |
| Popis: | Introduction: Chronic hepatitis B (CHB) patients with metabolic syndrome (MetS) may present increased risk of liver-related outcomes (LROs), but prior studies were limited by small sample size and/or conflicting results. Using a systematic review and meta-analytic approach, we aimed to determine the association between MetS and LROs in CHB. Methods: Two researchers independently screened studies from the PubMed, Embase, Web of Science, and Cochrane Library databases from inception to January 21, 2020, and extracted the data. Estimates were pooled using a random-effects model. Results: We screened 2,228 articles and included 10 eligible studies (18,360 CHB patients, 2,557 with MetS). MetS was significantly associated with LROs overall (odds ratio = 2.45, 95% confidence interval = 1.39–4.32) but not the individual LRO components but subgroup analyses were limited by small study numbers. Discussion/Conclusion: MetS is associated with almost 3-folds higher risk of LROs in CHB and should be considered in management decisions. However, additional studies are needed. |
| Databáze: | OpenAIRE |
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