Gd-DTPA-coupled Ag2Se quantum dots for dual-modality magnetic resonance imaging and fluorescence imaging in the second near-infrared window
| Autor: | Zhi-Quan Tian, Dai-Wen Pang, Jiao-Jiao Ma, Zheng Zhang, Hui-Li Zhu, Mingxia Yu, Wei-Guo Cai, Qing-Yuan Cheng, Zhi-Ling Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Materials science medicine.diagnostic_test Near-infrared spectroscopy technology industry and agriculture Magnetic resonance imaging 02 engineering and technology equipment and supplies 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Fluorescence 0104 chemical sciences Nuclear magnetic resonance Quantum dot Temporal resolution High spatial resolution medicine Dual modality General Materials Science 0210 nano-technology |
| Zdroj: | Nanoscale. 10:10699-10704 |
| ISSN: | 2040-3372 2040-3364 |
| Popis: | Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging. Herein, second near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with gadopentetate dimeglumine injection (Gd-DTPA) for dual-modality T1-weighted magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments suggested that the prepared Ag2Se-Gd QDs exhibit low cytotoxicity, remarkable T1-weighted MR imaging, and fluorescence imaging contrast properties. In vivo experiment results showed that Ag2Se-Gd QDs were the preferred contrast agents for dual-modality T1-weighted MR imaging and fluorescence imaging with high spatial resolution. Moreover, excellent temporal resolution and high tissue penetration depth were also achieved by fluorescence imaging. These results indicate the potential of Ag2Se-Gd QDs as multifunctional contrast agents for multimodal imaging in clinical diagnosis and research. |
| Databáze: | OpenAIRE |
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