Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen
| Autor: | Giovanna Pitarresi, Bianca Carlisi, Gaetano Giammona, Giacomo Fontana |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Ketoprofen
chemistry.chemical_classification Polymers and Plastics Chemistry medicine.drug_class 0206 medical engineering Bioengineering 02 engineering and technology Polymer Prodrug Alclofenac 021001 nanoscience & nanotechnology Ibuprofen 020601 biomedical engineering Anti-inflammatory Adduct Biomaterials Polymer chemistry Materials Chemistry medicine Organic chemistry 0210 nano-technology Drug carrier medicine.drug |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 6:129-141 |
| ISSN: | 1530-8030 0883-9115 |
| Popis: | Macromolecular prodrugs of a hydrophilic polymer [α,β-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied. |
| Databáze: | OpenAIRE |
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