| Autor: | T. G. Khlopushina, O. I. Mikovskaya, Basharova La, N. A. Trekova, L. A. Vetrile |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
C57BL/6
medicine.medical_specialty biology business.industry General Neuroscience biology.organism_classification Open field medicine.anatomical_structure Monoamine neurotransmitter Endocrinology Cerebral cortex Dopamine Internal medicine Hyperalgesia medicine biology.protein Serotonin Antibody medicine.symptom business medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 31:7-13 |
| ISSN: | 0097-0549 |
| Popis: | Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed. |
| Databáze: | OpenAIRE |
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