Synthesis and cytotoxic activity of new 4′-deoxy C-3′-homo anthracyclines

Autor:	J.-C. Jacquesy, Jean-Pierre Gesson, B. Renoux
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Organic Chemistry Glycoside Biological activity Biochemistry In vitro Quinone chemistry.chemical_compound Daunosamine Cell culture Drug Discovery Cytotoxic T cell Cytotoxicity
Zdroj:	Tetrahedron. 50:1165-1172
ISSN:	0040-4020
Popis:	Starting from (S)-propylene oxide, the protected C-3 homolog of 4-deoxy daunosamine 11 is prepared in 4 steps. Acid catalyzed glycosidation of anthracyclinones such as daunomycinone, β-rhodomycinone and e-isorhodomycinone with 11 affords new analogs of anthracyclines demonstrating strong cytotoxicity against L1210 leukemia, A-549 and HT-29 tumor cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::54328a3bf164d02dc4063c54c3552060 https://doi.org/10.1016/s0040-4020(01)80827-9 Zobrazit plný text záznamu