Synthesis and cytotoxic activity of new 4′-deoxy C-3′-homo anthracyclines
Autor: | J.-C. Jacquesy, Jean-Pierre Gesson, B. Renoux |
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Rok vydání: | 1994 |
Předmět: | |
Zdroj: | Tetrahedron. 50:1165-1172 |
ISSN: | 0040-4020 |
Popis: | Starting from (S)-propylene oxide, the protected C-3 homolog of 4-deoxy daunosamine 11 is prepared in 4 steps. Acid catalyzed glycosidation of anthracyclinones such as daunomycinone, β-rhodomycinone and e-isorhodomycinone with 11 affords new analogs of anthracyclines demonstrating strong cytotoxicity against L1210 leukemia, A-549 and HT-29 tumor cells. |
Databáze: | OpenAIRE |
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