Structural Studies of Intermediates in the Synthesis of Mifepristone (RU 486). II. Structure of a β-Epoxy Steroid
| Autor: | M. Machender Reddy, M. Bidya Sagar, A. V. Rama Rao, Krishnan Ravikumar, A. K. Singh |
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| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Double bond Chemistry Stereochemistry Propynyl medicine.medical_treatment General Medicine Epoxy Crystal structure General Biochemistry Genetics and Molecular Biology Steroid Crystallography chemistry.chemical_compound Molecular geometry visual_art Atom visual_art.visual_art_medium medicine Molecule |
| Zdroj: | Acta Crystallographica Section C Crystal Structure Communications. 51:451-454 |
| ISSN: | 0108-2701 |
| DOI: | 10.1107/s0108270194008589 |
| Popis: | Structure determination of the title compound, 5β,10-β-epoxy-3,3-ethylenedioxy-17β-hydroxy-17α-(1-propynyl)estra-9(11)-ene, C 23 H 30 O 4 , establishes the configuration of the epoxy O atom as 5β,10β and locates the position of the double bond between C(9) and C(11). The strain caused by the presence of an epoxy O atom between C(5) and C(10) in the molecule is reflected in the distortion of bond angles around several tetrahedral C atoms. The propynyl group is oriented perpendicular to the steroid skeleton. The molecules are hydrogen-bonded head-to-tail through hydroxyl groups |
| Databáze: | OpenAIRE |
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