Synthesis and properties of novel hydrogels from oxidized pectin crosslinked gelatin for biomedical applications

Autor: Asma Chetouani, Djafer Benachour, Mahmoud Bounekhel, Meriem Elkolli
Rok vydání: 2014
Předmět:
Zdroj: Polymer Bulletin. 71:2303-2316
ISSN: 1436-2449
0170-0839
DOI: 10.1007/s00289-014-1189-z
Popis: Gelatin (G) edible films with a new kind of dialdehyde polysaccharide, oxidized pectin (OP) as crosslinking agent are successfully prepared using casting techniques. FTIR and X-ray diffraction studies demonstrate that crosslinking is achieved through the reaction of aldehyde groups of oxidized pectin with the free amino groups in gelatin with a small affectation of the triple helix of gelatin. The qualitative and quantitative data about structures of films were determined by atomic force microscopy. Thermogravimetric analysis reveals that G/OP film has improved thermal stability in comparison with pure gelatin. Examination of the hemolytic potential showed that the obtained hydrogels are non-hemolytic in nature. These hydrogels are also nontoxic and blood-compatible. This kind of hydrogel is expected to be useful in the biomedical field, e.g., as wound dressing.
Databáze: OpenAIRE