MHC Class I Family Proteins Retard Systemic Lupus Erythematosus Autoimmunity and B Cell Lymphomagenesis

Autor:	Derry C. Roopenian, Dong-Mi Shin, William H. Schott, Jason A. Bubier, Thomas J. Sproule, Herbert C. Morse, Caroline G. McPhee, Martin P. Steinbuck, Lia Avenesyan
Rok vydání:	2011
Předmět:	MHC class II MHC Class I Protein Lupus erythematosus biology Immunology CD1 medicine.disease_cause medicine.disease Autoimmunity medicine.anatomical_structure immune system diseases MHC class I medicine biology.protein Immunology and Allergy B cell CD8
Zdroj:	The Journal of Immunology. 187:4695-4704
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.1101776
Popis:	Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8+ T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::54206f38811a0bbdbcb04dbf1f1166f4 https://doi.org/10.4049/jimmunol.1101776 Zobrazit plný text záznamu