New actionable targets and investigational drugs in chronic lymphocytic leukemia
Autor: | Jan-Paul Bohn |
---|---|
Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty Chemotherapy biology business.industry Chronic lymphocytic leukemia medicine.medical_treatment Hematology Drug resistance Disease medicine.disease Clinical trial Internal medicine Investigational Drugs medicine biology.protein Bruton's tyrosine kinase business Tyrosine kinase |
Zdroj: | memo - Magazine of European Medical Oncology. 15:53-57 |
ISSN: | 1865-5076 1865-5041 |
Popis: | SummaryThe treatment landscape of chronic lymphocytic leukemia (CLL) has shifted from chemotherapy-based approaches to targeted agents in the last decade. However, evolving drug resistance and accumulating toxicity remain challenges that still limit patients’ clinical outcomes. Furthermore, currently licensed targeted agents such as inhibitors of Bruton’s tyrosine kinase (BTK) and anti-apoptotic protein B‑cell lymphoma 2 (BCL2) do not adequately compensate for the poor clinical outcomes associated with high-risk genetics such as TP53 alterations. New insights into disease biology facilitated design and investigation of several new targeted agents with encouraging results in early clinical trials. This short review focuses on novel actionable targets and investigational drugs aimed at circumventing acquired resistance and avoiding accumulating toxicity. |
Databáze: | OpenAIRE |
Externí odkaz: |