Sampling of Hypophyseal Portal Blood of Conscious Sheep for Direct Monitoring of Hypothalamic Neurosecretory Substances
| Autor: | Alain Caraty, Fred J. Karsch, Alain Locatelli, Suzanne M. Moenter |
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| Rok vydání: | 1994 |
| Předmět: |
0303 health sciences
Surgical approach Continuous sampling business.industry 030209 endocrinology & metabolism Anatomy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Anterior pituitary Portal blood Pituitary hormones medicine Fully conscious Direct monitoring Adult sheep business 030304 developmental biology |
| DOI: | 10.1016/b978-0-12-185289-4.50015-2 |
| Popis: | Publisher Summary This chapter describes a procedure for remote continuous sampling of hypophyseal portal blood of sheep. The procedure offers advantages over earlier methods for portal blood collection because it allows both hypothalamic and pituitary hormones to be monitored for prolonged periods from animals that are fully conscious and apparently undisturbed. Additional exciting new applications should arise by combining the procedure with other techniques used in neuroendocrine investigation, for example, electrical stimulation and recording as well as the local delivery of regulatory substances to discrete neuroendocrine centers implicated in the control of anterior pituitary function. The procedure should be adaptable to species other than sheep, given certain anatomical features of the pituitary and its vasculature. In this regard, four features of the sheep make it especially well suited. The first is the angle of the pituitary. The anterior face of the pituitary of most adult sheep hangs nearly perpendicularly from the base of the brain such that the densest array of portal vessels is readily accessible for surgical approach. |
| Databáze: | OpenAIRE |
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