Successful Combination Therapy of Nivolumab and Radiation for Massive Mucosal Melanoma in Patient with Autoimmune-Myasthenia Gravis, Systemic Lupus Erythematosus and Rheumatoid Arthritis

Autor:	Kohei Tsujimoto, Reika Aoyama, Toshiro Tanaka, Ichiro Katayama, Yorihisa Kotobuki, Shigeaki Suzuki, Keita Kakuta, Atsushi Tanemura, Asako Ota
Rok vydání:	2018
Předmět:	medicine.medical_specialty Combination therapy business.industry Melanoma medicine.medical_treatment Mucosal melanoma Rectum medicine.disease Dermatology Myasthenia gravis Radiation therapy medicine.anatomical_structure Rheumatoid arthritis Medicine Nivolumab business
Zdroj:	Journal of Cosmetics, Dermatological Sciences and Applications. :35-38
ISSN:	2161-4512 2161-4105
Popis:	A 58-year-old woman complicated with autoimmune diseases of myasthenia gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an irregular black macule on her bilateral major labia, which was diagnosed as malignant melanoma. The melanoma lesion involving the vagina, uterus, and ventral side of rectum was not operable and was treated with nivolumab and concurrent radiotherapy with good control of the MG. This resulted in remarkable tumor shrinkage, possibly due to synergistic effects of both treatments. To our knowledge, few reports have described the effectiveness of combination therapy with nivolumab and radiation for malignant melanoma. The present case showed an enhanced anti-tumor effect with combination therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::540fcc971bec06d9c2b6b49b94a1d05f https://doi.org/10.4236/jcdsa.2018.81006 Zobrazit plný text záznamu