| Autor: |
Naïma Hanoun, Mohamed Bidri, René Lai Kuen, Frédéric Féger, Dominique Mazier, Marc Conti, Ioannis Vouldoukis, Michel Arock, Zacharie Taoufiq |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
The Open Parasitology Journal. 2:43-50 |
| ISSN: |
1874-4214 |
| Popis: |
Biological functions of mast cells include a functional role in innate immunity against parasitic infections. Here, we demonstrated that mast cells could also play a role in the anti-microbial defenses regulation and might partici- pate as a parasite reservoir. We observed that Toxoplasma gondii infected massively in vitro mouse bone marrow derived mast cells (BMMC), a mucosal mast cell (MMC) phenotype, followed by substantial cell lysis. This induced release of - hexosaminidase, but not of preformed or neosynthesized TNF- . Culturing MMC in the presence of recombinant mouse stem cell factor (c-kit ligand) led to their maturation into connective tissue-like mast cells (CTMC), which T. gondii was able to adhere on and to infect more. T. gondii infection did not induce release of -hexosaminidase and serotonin from BMMC. These results demonstrated that mast cells interact with T. gondii and are massively infected, especially after their maturation by c-kit ligand. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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