Isolation, structural elucidation and synthesis of a novel antioxidative pseudo-di-peptide, Hanasanagin, and its biogenetic precursor from the Isaria japonica mushroom

Autor:	Kazufumi Shioya, Akira Sakakura, Takashi Komiya, Toshikatsu Imamura, Kunio Imai, Yasuo Aizono, Hirotaka Katsuzaki
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Mushroom Dipeptide Chemistry Stereochemistry Chemical structure fungi Organic Chemistry food and beverages Peptide Pharmacognosy Biochemistry Chemical synthesis chemistry.chemical_compound Enzyme Drug Discovery Medicinal fungi
Zdroj:	Tetrahedron. 65:6822-6827
ISSN:	0040-4020
DOI:	10.1016/j.tet.2009.06.069
Popis:	The entomogenous ‘Hanasanagitake’ mushroom, Isaria japonica, is used as a folk medicine and as a traditional health food choice in Japan. A search for naturally occurring antioxidative compounds from the mushroom led to the isolation of a novel pseudo-di-peptide, named Hanasanagin, and a possible biogenetic precursor. The structures of the pseudo-di-peptides were determined as (R)-3,4-diguanidinobutanoyl-(S)-DOPA and (R)-3,4-diguanidinobutanoyl-(S)-tyrosine by spectral analysis, chemical synthesis and enzymatic conversion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::540d2ff037decaf6b8d22dc7ac01ee71 https://doi.org/10.1016/j.tet.2009.06.069 Zobrazit plný text záznamu Full Text from ScienceDirect