The role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity
| Autor: | T. S. Popova, Yu. V. Gurman, N. S. Tropskaya |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal Biomed. 17:147-150 |
| ISSN: | 2713-0428 2074-5982 |
| Popis: | On a sample of 14 rats, the role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity under the conditions of 18-hour food deprivation in a chronic experiment was studied. Administration of GABA at a dose of 70 mg/kg resulted in stimulation of phase II (irregular activity) and the disappearance of phases I (rest) and III (regular activity) of the migrating myoelectric complex (MMC). The main effect of the M-cholinoblockator — atropine (1 mg/kg) was manifested in the disappearance of phase III MMC. The administration of GABA after the administration of atropine caused the appearance of extraordinary phase III MMC, thereby exerting a release effect on the regular (propulsive) activity of the small intestine. Therefore, one of the mechanisms of GABA action on the electrical activity of the small intestine is cholinergic pathways. |
| Databáze: | OpenAIRE |
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