Metabolic and Hormonal Responses during a Glucose Contrlled Insulin Infusion (Biostator®) in Subjects with Imparied Glucose Tolerance1)
| Autor: | Schneider U, Schulz B, Peters U, Ratzmann Kp, Manfred Ziegler |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism General Medicine Metabolism Biology medicine.disease Artificial pancreas Impaired glucose tolerance chemistry.chemical_compound Insulin infusion Endocrinology NEFA Glucose infusion chemistry Internal medicine Internal Medicine medicine Glycerol Hormone |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 83:334-342 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210350 |
| Popis: | The short-term effect of the glucose-controlled insulin infusion system (GCIIS) Biostator on metabolic and hormonal responses was studied in 10 non-obese subjects with glucose intolerance and insulin low response to glucose. Glucose tolerance characterized by means of a 2 h glucose infusion test (12 mg/kg/min) primed by i.v. injection of 0.33 g glucose/kg body weight was completely normalized by GCIIS. Results provide further support that normalization of glucose tolerance by means of GCIIS is accompanied by peripheral hyperinsulinaemia if compared with 33 non-obese healthy controls. Glucose-induced endogenous insulin secretion (C-peptide) was significantly reduced during the GCIIS study possibly due to inhibition of insulin secretion by exogenous insulin and/or by lower blood glucose concentration after normalization of glucose tolerance. Acute normalization of glucose tolerance in these patients failed to alter pancreatic glucagon, NEFA and glycerol responses but normalized paradoxical growth hormone response to glucose. |
| Databáze: | OpenAIRE |
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