| Autor: |
Shahlaa M Salih, Amal M. Ali |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
NeuroQuantology. 19:115-121 |
| ISSN: |
1303-5150 |
| DOI: |
10.14704/nq.2021.19.6.nq21076 |
| Popis: |
Background: Acute myeloid leukemia (AML) is a hematopoietic disorder in which there are too many immature blood-forming cells accumulating in the bone marrow and interfering with the production of normal blood cells. It has long been recognized that AML is a clinically heterogeneous disease characterized by a multitude of chromosomal abnormalities and gene mutations, which translate to marked differences in responses and survival following chemotherapy. This study aimed to clarify the chromosomal aberrations in early diagnosed and relapsed cases of AML. Materials and methods: Chromosomal changes were studied in thirty Iraqi patient samples diagnosed with acute myeloid leukemia were divided into 9 newly diagnosed and 13 received chemotherapy who were incomplete remission and 8 relapsed subjects. Results: Analysis of all chromosomal aberrations showed complex karyotype for most cells of relapsed AML patients compared with newly diagnosed patients. Conclusions: Chromosomal abnormalities are linked to AML development and high complexity of karyotyping for relapsed group. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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