Association between osteoarthritis and increased risk of dementia
| Autor: | Adrian Weber, Shing Hung Mak, Francis Berenbaum, Yongping Zheng, Chunyi Wen, Yifan Han, Jérémie Sellam |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Funnel plot business.industry General Medicine Publication bias medicine.disease Confidence interval 3. Good health 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis Internal medicine Cohort Medicine Dementia 030212 general & internal medicine business Vascular dementia Prospective cohort study |
| Zdroj: | Medicine. 98:e14355 |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000014355 |
| Popis: | OBJECTIVE To investigate the possible association between osteoarthritis (OA) and the risk of dementia. METHODS Cohort, case-control, and cross-sectional studies were obtained from wide literature search up to 20 April 2018 from following electronic databases: PubMed, Embase, Cochrane, using the MeSH terms: "osteoarthritis" AND "dementia". The literature search was then expanded to congress abstracts. After screening and selection of relevant studies by two investigators, data was extracted. Estimates were then calculated using a random-effect size model. Sensitivity-analysis was conducted for gender and age adjusted studies and pooled for studies with STROBE quality assessment score ≥75%. Publication bias was assessed by Funnel plot. Analyses were performed using Data Analysis and Statistical Software Version 14.2. RESULTS Nearly 1549 publication references were initially retrieved. Twenty-six publications were checked with full-text. Six observational studies with 388,252 individuals were included. OA was associated with a significantly increased risk for dementia (OR = 1.20; 95% confidence interval (CI), 1.03-1.39, I = 95.6%, P |
| Databáze: | OpenAIRE |
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