| Popis: |
Since its identification more than 30 years ago (see Roberts, 1975), as a naturally occurring brain substance that inhibited neural activity, γ-aminobutyric acid (GABA) has become recognized as one of the major neurotransmitter agents of the mammalian central nervous system. The ubiquitous distribution of GABA neurons and GABA receptors and the demonstrable role of GABA in shaping, through inhibition, the stimulus—response properties of neurons at many levels of the central nervous system attest to its profound functional importance. In most of the major organized systems of the neuraxis, GABA can probably be regarded as occupying a status equal in importance to that of the excitatory amino acid transmitters. |
