Synthesis and antiretroviral evaluation of 3-alkyl 2-piperazinone nucleoside analogs

Autor:	Sylvie Delebassée, Abdellah Benjahad, Robert Granet, Mourad Kaouadji, R. Benhaddou, Pierre Krausz, Claudine Bosgiraud, Salomon Piekarski, François Thomasson
Rok vydání:	1994
Předmět:	chemistry.chemical_classification In vitro test Glycosylation Nucleoside analogue Stereochemistry Organic Chemistry Biochemistry chemistry.chemical_compound chemistry Drug Discovery medicine lipids (amino acids peptides and proteins) Alkyl medicine.drug
Zdroj:	Tetrahedron Letters. 35:9545-9548
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)88507-9
Popis:	Glycosylation of 3-alkyl N 4 -(3-hydroxypropyl) 2-piperazinones by protected 1- O -acetyl ribofuranoses produces nucleoside analogs in which the base is separated from the sugar by a hydrocarbon spacer arm. The preliminary in vitro test results against retroviruses seem promising for compounds bearing a long alkyl chain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::53e4500c8cc51a3c4c493d8dab8bd54a https://doi.org/10.1016/0040-4039(94)88507-9 Zobrazit plný text záznamu