Mutations in Sodium Channel Gene SCN9A and the Pain Perception Disorders

Autor:	Radmilo Jankovic, Danica Marković, Ines Veselinović
Rok vydání:	2015
Předmět:	Pain disorder business.industry Sodium channel gene Sodium channel General Medicine medicine.disease Bioinformatics Pathophysiology Anesthesia medicine Pain perception Myocyte SCN9A Gene business Gene
Zdroj:	Advances in Anesthesiology. 2015:1-6
ISSN:	2314-7555 2356-6574
Popis:	Voltage-gated sodium channels (NaV) play a crucial role in development and propagation of action potentials in neurons and muscle cells. NaV1.7 channels take a special place in modern science since it is believed that they contribute to nerve hyperexcitability. Mutations of the gene SCN9A, which codes the α subunit of NaV1.7 channels, are associated with pain perception disorders (primary erythermalgia, congenital analgesia, and paroxysmal pain disorder). It is considered that the SCN9A gene mutations may cause variations in sensitivity to pain, from complete insensitivity to extreme sensitivity. Further research of the SCN9A gene polymorphism influence on pain sensitivity is essential for the understanding of the pathophysiology of pain and the development of the appropriate targeted pain treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::53d89443370eba99a23160cd74d4e6b7 https://doi.org/10.1155/2015/562378 Zobrazit plný text záznamu Plný text