(−)-Epigallocatechin 3-O-Gallate as a New Approach for the Treatment of Visceral Leishmaniasis
| Autor: | Elmo E. Almeida-Amaral, Job D. F. Inacio, Myslene S Fonseca |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
Pharmacology 01 natural sciences Parasite load Analytical Chemistry In vivo Oral administration Drug Discovery medicine ED50 EC50 biology 010405 organic chemistry business.industry Organic Chemistry Leishmaniasis medicine.disease biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Visceral leishmaniasis Complementary and alternative medicine Molecular Medicine Leishmania infantum business |
| Zdroj: | Journal of Natural Products. 82:2664-2667 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00632 |
| Popis: | In addition to generating side effects and resistance, treatment for visceral leishmaniasis remains mostly ineffective and expensive, and it has a long duration. Thus, natural products are an important alternative for treatment of the disease. In this study, we demonstrate the in vitro and in vivo activity of (-)-epigallocatechin 3-O-gallate (1) against Leishmania infantum. Compound 1 reduced the infection index with an EC50 value of 2.6 μM. Oral administration of 1 on L. infantum-infected BALB/c mice was capable to reduce the liver-parasite load with a ED50 and ED90 value of 12.4 and 21.5 mg/kg/day, respectively. Together, the results demonstrated 1 as a new compound for the treatment of visceral leishmaniasis. |
| Databáze: | OpenAIRE |
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