Monoclonal Antibodies Hypersensitivity
| Autor: | Violeta Régnier Galvão, Rafael Bonamichi Santos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
biology
Drug desensitization medicine.drug_class business.industry medicine.medical_treatment Immunology Drug allergy Tryptase Skin test Immunotherapy Immunoglobulin E Monoclonal antibody medicine.disease 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Antibodies monoclonal 030220 oncology & carcinogenesis biology.protein medicine Immunology and Allergy business |
| Zdroj: | Immunology and Allergy Clinics of North America. 37:695-711 |
| ISSN: | 0889-8561 |
| Popis: | The use of monoclonal antibodies (mAbs) has become broader because of their recognized effectiveness in the treatment of autoimmune, neoplastic, and inflammatory diseases. Consequently, hypersensitivity reactions (HSR) secondary to mAbs are being reported more often, and each mAb-related HSR presents specific features. This article discusses the main biological agents and associated HSR, the clinical presentation of such reactions, and the role of tryptase and skin testing in the diagnosis. Rapid drug desensitization procedures to mAbs enable selected allergic patients to receive full therapeutic doses in a safe manner and are also discussed. |
| Databáze: | OpenAIRE |
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