| Popis: |
Immune globulins (IG) may cause adverse vasoactive reactions. Twenty-four IG solutions (16.5% protein) made by 5 manufacturers were analyzed for components of the contact-activation system, which could mediate such reactions. Kallikrein (K) was measured with S-2302 as the substrate and prekallikrein activator (PKA), by its activation of prekallikrein to K with [3H]TAME, BAEE, or S-2302 as the substrate. Capillary permeability (CP) was determined by intradermal injection of IG into guinea pigs pretreated with Evans Blue dye. The K activity in the 24 lots ranged from |
