| Popis: |
Purpose Inconsistent reports of the association between tumor necrosis factor-alpha (TNF-α) 308G/A single nucleotide polymorphism (SNP) and allergic rhinitis (AR) prompted a meta-analysis to determine a relatively precise and reliable linkage between TNF-α-308G/A gene polymorphism and risk of AR. Methods PubMed, Web of Science, Excerpta Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), and Wanfang Database were used to search all published case-control studies on the relationship between TNF-α-308G/A polymorphism and susceptibility to AR. Data for each study were extracted using standardized forms, and summary odds ratios (ORs), with 95% confidence intervals (CIs) used to evaluate the intensity of the association by RevMan 5.4.1 software. Results 7 studies (1383 AR cases and 1313 controls) were obtained for the meta-analysis. Comprehensive results showed that the polymorphism of TNF-α-308G/A gene was significantly associated with increased AR risk in the following two models: (1) AA vs. GG + GA: OR = 2.91, P = 0.003; (2) AA vs. GG: OR = 3.89, P = 0.0002. When participants were stratified by race, the TNF-α-308G/A polymorphism showed obviously increased AR risk in Asians under the following three models: (1) AA vs. GG + GA: OR = 3.08, P = 0.004; (2) AA vs. GG: OR = 4.38, P = 0.0002. In Europe, however, no obvious correlation was detected in any genetic models. Conclusions The results of our present analysis indicated that the TNF-α-308G/A gene polymorphism was associated with the susceptibility of AR, especially within the Asian population. |
