Pengaruh Ekstrak Daun Pedada (Sonneratia caseolaris) Sebagai Antihiperkolesterolmia Pada Mencit (Mus musculus)
| Autor: | Ramlah Ramlah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Traditional medicine Cholesterol food and beverages Sonneratia caseolaris biology.organism_classification Normal group chemistry.chemical_compound chemistry Lower total cholesterol Simvastatin Maceration (wine) medicine General Earth and Planetary Sciences Carboxy methyl cellulose Completely randomized design General Environmental Science medicine.drug |
| Zdroj: | bionature. 19 |
| ISSN: | 2654-5160 1411-4720 |
| DOI: | 10.35580/bionature.v19i1.6629 |
| Popis: | This study was conducted to determine the effect of extract leaf pedada ( Sonneratia caseolaris ) to total cholesterol levels of mice ( Mus musculus ) male ICR strain. Leaf pedada extracted using 96% methanol by maceration. This study is a completely randomized design (CRD), which consists of 5 treatments and 5 replicates the normal group (distilled water), positive group (Simvastatin), a group of leaf pedada extract at a dose of 125, 250 and 500 mg / kg. The extract was dissolved using Carboxy Methyl Cellulose (CMC) 0.5% and given orally in mice which had previously been given a high cholesterol feed. The results showed the methanol extract of leaves cemba with the dose of 500 mg/kg hads the highest effectiveness in lowering total cholesterol levels in mice which have hypercholesterolemia with a 30,20 % percentage drop. These results indicate that of the giving leaf extract pedada ( Sonneratia caseolaris ) able to lower total cholesterol levels of mice ( Mus musculus ) male hypercholesterolaemia. Keywords : Antihipercholesterolemia, total cholesterol, Methanol extract of leaf pedada ( Sonneratia caseolaris ), mice ( Mus musculus ) ICR male. |
| Databáze: | OpenAIRE |
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