Genetics of Lipoprotein(a)
| Autor: | H. G. Kraft |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Linkage disequilibrium Low-density lipoprotein receptor-related protein 8 biology Apolipoprotein B Lipoprotein(a) Twin study Endocrinology chemistry Internal medicine biology.protein medicine lipids (amino acids peptides and proteins) Glycoprotein Gene Lipoprotein |
| Zdroj: | From Molecule to Men ISBN: 9783642633386 |
| Popis: | Lipoprotein(a) [Lp(a)] is a complex in human plasma consisting of an LDL particle to which a glycoprotein designated apolipoprotein(a) [apo(a)] is bound via a disulfide bridge. High levels of lipoprotein(a) are considered as genetic risk factor for premature atherosclerosis. Lp(a) plasma levels vary over 1000-fold between individuals. Sib-pair and twin studies have revealed that in Caucasians this variation of Lp(a) concentrations is almost completely determined by the gene locus of one of its protein constituents, namely apo(a). Here we describe the effect of 4 polymorphisms in the apo(a) gene on Lp(a) levels in 4 populations from Africa, and Europe and their relation with coronary heart disease (CHD). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|