Tumor-associated macrophages and heparanase in lung cancer microenvironment. (TUM6P.970)
| Autor: | Morgana Castelo-Branco, Heitor Souza, Marcos Paschoal, Mauro Pavão, Vivian Rumjanek |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:141.18-141.18 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Tumor-associated macrophages promote aspects of tumor initiation, growth, and progression. Tumor growth takes place in a complex microenvironment of stromal cells and extracellular matrix. Heparanase is the only known mammalian glycosidase capable of cleaving heparan sulfate. Its expression has been associated with tumor development. Immunohistochemistry and immunofluorescence were performed in samples of 37 lung cancer patients to assess heparanase, macrophages and lymphocytes presence and localization. All types of tumors expressed heparanase within the cytoplasm and nucleus. Adenocarcinoma showed the highest intensity and widespread distribution. The other types had similar intensity with a less widespread distribution. Tumor surroundings also presented heparanase co-expression with fibroblast, macrophages and epithelial cells. Heparanase expression correlates to TNM staging. The heparanase possesses a different distribution according to the type of lung tumor. Heparanase from fibroblasts might regulate the tumor microenvironment through HS cleavage, by enabling invasion and release of growth factors from extracellular matrix. We showed lung cancer TAMs expressing heparanase and described heparanase localization in the tumor microenvironment providing knowledge concerning lung cancer. Therefore, we suggest that heparanase can constitute a possible therapeutic target for lung carcinoma and that macrophages are attractive targets as part of combination therapy in cancer. |
| Databáze: | OpenAIRE |
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