4,7,11-Triheterotrishomocubanes – Propeller-Shaped Highly Symmetrical Chiral Molecules Derived from Barrelene
Autor: | Sergei I. Kozhushkov, Thomas Preuß, Dmitrii S. Yufit, Stephan Rühl, Yoshio Okamoto, Chiyo Yamamoto, Armin de Meijere, B. Christopher Rinderspacher, Judith A. K. Howard, Peter R. Schreiner, Kathrin Meindl |
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Rok vydání: | 2006 |
Předmět: |
010405 organic chemistry
Chemistry Stereochemistry Organic Chemistry Barrelene Absolute configuration Crystal structure Aziridine 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Yield (chemistry) Specific rotation Physical and Theoretical Chemistry Enantiomer Chirality (chemistry) |
Zdroj: | European Journal of Organic Chemistry. 2006:2590-2600 |
ISSN: | 1099-0690 1434-193X |
Popis: | Epoxidation of barrelene (3) with a neutralized solution of Oxone® gave the barrelene trisepoxide 6 in 82 % isolated yield, while lead tetraacetate promoted aziridination of 3 with two equiv. of N-aminophthalimide gave a mixture of mono-7 and bis(aziridine) endo,exo-8, which were isolated in 67 and 8 % yield, respectively. Fourfold repetition of this aziridination gave the bis(aziridines) exo,exo- and endo,exo-8 along with the trisaziridine 9 in 21, 8 and 19 % yield, respectively. Epoxidation of 7 and endo,exo-8 with buffered m-chloroperbenzoic acid furnished the dioxaazatrishomobarrelene 10 and oxadiazatrishomobarrelene 11 in 36 and 62 % yield, respectively. The structures of triheteratrishomobarrelenes 6 and 9 were established by X-ray crystallography. Upon treatment with BF3·Et2O at –20 °C (for 6) or with the strongly acidic ion exchange resin Amberlyst 15 at ambient or elevated temperatures (for 9–11), these triheteratrishomobarrelenes rearrange to give the triheteratrishomocubanes rac-12 to rac-15, as proved by X-ray crystal structure analysis of rac-13, in 75–100 % yield. The enantiomeric pairs of trioxa- 12 and triazatrishomocubane 13 were separated by preparative HPLC on a chiral column. 12 exhibited specific rotationsof [α]D25 = +196 and [α]36525 = +652 (c = 0.497, CHCl3) for the firstly eluted and [α]D25 = –173 and [α]36525 = –608 (c = 0.503, CHCl3) for the secondly eluted enantiomer; 13 had [α]D25 = +30 and [α]43525 = +501 (c = 0.490, CHCl3) for the firstly as well as [α]D25 = –28 and [α]43525 = –475 (c = 0.501, CHCl3) for the secondly eluted enantiomer. The geometry of rac-13 and the absolute configurations of (–)-12 and (+)-13 were determined by X-ray crystal structure analyses. According to this, (–)-12 and (+)-13 possess the same (1R,3R,5R,6R,8R,10R)-configuration. Theabsolute configuration of the former was also confirmed byDFT computations at the TD-B3LYP/6-31+G(d,p)//B3LYP/6-31+G(d) level of theory; the computed specific rotation for (–)-12 was –178. Computations for the elusive (all-R)-triazatrishomocubane (all-R)-13-H without phthalimidyl substituents on the nitrogen atoms disclosed that the sign of rotation is the same for the parent (all-R)-13-H and (all-R)-trioxatrishomocubane (all-R)-12 with the same absolute configuration. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) |
Databáze: | OpenAIRE |
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