Anti-Pyretic Activity of two Varieties of Hibiscus Rosa Sinensis L

Autor:	Zainul Amiruddin Zakaria, Mwh Abdul Aziz, AH Roslida, A. Zuraini, S.Z Raduan, Muhammad Nazrul Hakim
Rok vydání:	2021
Předmět:	Pharmacology 03 medical and health sciences 0302 clinical medicine biology Traditional medicine business.industry 030232 urology & nephrology Medicine Hibiscus rosa-sinensis Anti pyretic 030204 cardiovascular system & hematology business biology.organism_classification
Zdroj:	Biomedical and Pharmacology Journal. 14:61-74
ISSN:	2456-2610 0974-6242
DOI:	10.13005/bpj/2099
Popis:	Hibiscus rosa-sinensis has been traditionally used by local communities to treat fever. However, there are only limited data have been published to support the antipyretic effects. The objective of this study is to investigate the antipyretic properties and possible mechanism of the ethanol extracts of Hibiscus rosa-sinensisL. (red colored flower) and Hibiscus rosa-sinensisvar. Alba (white colored flower). Phytochemical analysis, heavy metals screening and acute toxicity test were done to evaluate the safety of extracts. The first model ran induced fever in rats by injecting Brewer's Yeast subcutaneously and then treated with 4 extracts at dosage 5 & 50 mg/kg. The dosages used for the study were obtained by the acute toxicity test. Ibuprofen was used as a reference drug, with dose 100 mg/kg. Temperatures of rats were measured using a digital thermometer. The results were expressed as mean ± S.E.M. and analyzed using the SAS system. The results of the study showed that white flower extract 5mg/kg and 50 mg/kg significantly (p
Databáze:	OpenAIRE
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