Biological effect of PM10 on airway epithelium-focus on obstructive lung diseases
| Autor: | Paulina Misiukiewicz-Stępień, Magdalena Paplińska-Goryca |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
COPD Lung Exacerbation business.industry Immunology Environmental pollution medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immunology and Allergy Respiratory epithelium Medicine Respiratory function Respiratory system business Airway 030215 immunology |
| Zdroj: | Clinical Immunology. 227:108754 |
| ISSN: | 1521-6616 |
| Popis: | Recently, a continuous increase in environmental pollution has been observed. Despite wide-scale efforts to reduce air pollutant emissions, the problem is still relevant. Exposure to elevated levels of airborne particles increased the incidence of respiratory diseases. PM10 constitute the largest fraction of air pollutants, containing particles with a diameter of less than 10 μm, metals, pollens, mineral dust and remnant material from anthropogenic activity. The natural airway defensive mechanisms against inhaled material, such as mucus layer, ciliary clearance and macrophage phagocytic activity, may be insufficient for proper respiratory function. The epithelium layer can be disrupted by ongoing oxidative stress and inflammatory processes induced by exposure to large amounts of inhaled particles as well as promote the development and exacerbation of obstructive lung diseases. This review draws attention to the current state of knowledge about the physical features of PM10 and its impact on airway epithelial cells, and obstructive pulmonary diseases. |
| Databáze: | OpenAIRE |
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